A strategy for direct mapping and identification of mutations by whole-genome sequencing
S Zuryn, S Le Gras, K Jamet, S Jarriault - Genetics, 2010 - academic.oup.com
S Zuryn, S Le Gras, K Jamet, S Jarriault
Genetics, 2010•academic.oup.comMutant screens have proven powerful for genetic dissection of a myriad of biological
processes, but subsequent identification and isolation of the causative mutations are usually
complex and time consuming. We have made the process easier by establishing a novel
strategy that employs whole-genome sequencing to simultaneously map and identify
mutations without the need for any prior genetic mapping.
processes, but subsequent identification and isolation of the causative mutations are usually
complex and time consuming. We have made the process easier by establishing a novel
strategy that employs whole-genome sequencing to simultaneously map and identify
mutations without the need for any prior genetic mapping.
Abstract
Mutant screens have proven powerful for genetic dissection of a myriad of biological processes, but subsequent identification and isolation of the causative mutations are usually complex and time consuming. We have made the process easier by establishing a novel strategy that employs whole-genome sequencing to simultaneously map and identify mutations without the need for any prior genetic mapping.
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