The quality and application of super-resolution fluorescence imaging greatly lie in the dyes'
properties, including photostability, brightness, and Stokes shift. Here we report a synergistic
strategy to simultaneously improve such properties of regular fluorophores. Introduction of
quinoxaline motif with fine-tuned electron density to conventional rhodamines generates
new dyes with vibration structure and inhibited twisted-intramolecular-charge-transfer (TICT)
formation synchronously, thus increasing the brightness and photostability while enlarging …

The quality and application of super-resolution fluorescence imaging greatly lie in the
properties of fluorescent probes. However, conventional fluorophores in a cellular
environment often suffer from low brightness, poor photostability, and short Stokes shift (< 30
nm). Here we report a synergistic strategy to simultaneously improve such properties of
regular fluorophores. Introduction of quinoxaline motif with fine-tuned electron density to
conventional rhodamines generates new dyes with vibronic structure and inhibited twisted …