Background Fatigue is common after traumatic brain injury (TBI). Its risk factors, natural
history and consequences are uncertain. Best-evidence synthesis was used to address the
gaps. Methods Five databases were searched for relevant peer-reviewed studies. Of the 33
articles appraised, 22 longitudinal studies were selected. Results were reported separately
based on their timing of baseline assessment. Results All studies document changes in
fatigue frequency and severity with time, irrespective of setting or TBI severity. There is …

Objective Fatigue is a common debilitating symptom after traumatic brain injury (TBI). Its risk
factors, natural history, and consequences are uncertain. We undertook a best-evidence
synthesis to address these gaps. Design MEDLINE, EMBASE, COCHRANE Database of
Systematic Reviews, CINAHL, and PsycINFO were systematically searched for relevant peer-
reviewed studies. Of 2745 abstracts and papers screened, 33 studies were critically
reviewed, and a final 22 (61%) English language longitudinal studies were included in this …