A theoretical and crystallographic study of the geometries and conformations of fluoro-olefins as peptide analogues

RJ Abraham, SLR Ellison, P Schonholzer, WA Thomas - Tetrahedron, 1986 - Elsevier
… -STO-3G level of approximation (34) led to a good agreement of calculated and
experimental geometries. In this study we have used a combination of molecular orbital
calculations and X-ray crystallography to investigate the structural and conformational
properties of a-fluoro-a,B-unsaturated acids as model fluoro-olefins. RESULTS AND
DISCUSSION THE CRYSTAL STRUCTURE OF 2-CYCLOHEXYLIDENE-2-FLUOROACETIC
ACID (1,. The crystal structure of 1 is summarised in Figure 1 and the accompanying table. …
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