… Figure 1Schematic of potential AAV access to the CNS from the periphery. (a) Retrograde
… AAV9 receptors. Several candidates are depicted, but this is not a complete list of possible …

… of AAV vector serotypes, AAV9. These new reports complement recent articles published in
MT and elsewhere suggesting that AAV9 … by rAAV9 trans-blood-brain barrier gene delivery. …

… for AAV9, we further compared AAV8 and AAV9 … AAV9 crossing at 72 h revealed that 5.3
× 10 6 vg AAV9 crossed the 4603-derived BBB while only 1.1 × 10 6 vg of AAV8 crossed. AAV9 …

… ROI as an effective route of AAV delivery, herein we aim to … Cre reporter mice) with the AAV9
vector, which targets a wide … aaV9: a potential blood-brain barrier buster. Mol Ther. 2009; …

… In furthering this exploration, we report the novel identification of human LY6E as a potential
mediator of AAV BBB transcytosis. Moreover, our computational analysis of the proposed …

… established that certain adeno-associated virus (AAV) serotypes, such as 9 and rh10, possess
an inherent capability to cross the blood-brain barrier and to transduce cells in the central …

… For instance, AAV serotype 9 (AAV9) can cross the blood–brain barrier (BBB) and, as a …
of an AAV9 vector engineered to express a single-chain scFv antibody against PD-1 (AAV9-scFv-…

… AAV variants, such as the synthetic AAV-inner ear (AAV-ie) … AAVie efficiently transduced all
cochlear SCs, and after AAV-ie… , and is equivalent to that of the blood-brain barrier (BBB) 15. …

… (rAAVs) can cross the neonatal blood–brain barrier (BBB) and efficiently transduce cells of
… CNS transduction is a common character of AAV serotypes tested. Of note, rAAVrh.8 is the …

… 9 (AAV9) has recently been shown to penetrate the blood–brain barrier via intravascular …
However, the potential side effects of systemic delivery are unknown. Intrathecal viral vector …