ADAMTS13 regulation of VWF multimer distribution in severe COVID‐19
Background Consistent with fulminant endothelial cell activation, elevated plasma von
Willebrand factor (VWF) antigen levels have been reported in patients with COVID‐19. The
multimeric size and function of VWF are normally regulated through A Disintegrin And
Metalloprotease with ThrombSpondin Motif type 1 motif, member 13 (ADAMTS‐13)‐‐
mediated proteolysis. Objectives This study investigated the hypothesis that ADAMTS‐13
regulation of VWF multimer distribution may be impaired in severe acute respiratory …
Willebrand factor (VWF) antigen levels have been reported in patients with COVID‐19. The
multimeric size and function of VWF are normally regulated through A Disintegrin And
Metalloprotease with ThrombSpondin Motif type 1 motif, member 13 (ADAMTS‐13)‐‐
mediated proteolysis. Objectives This study investigated the hypothesis that ADAMTS‐13
regulation of VWF multimer distribution may be impaired in severe acute respiratory …
ADAMTS13 regulation of VWF multimer distribution in severe COVID-19
S Enright Ward, H Fogarty, E Karampini, M Lavin… - 2021 - repository.rcsi.com
Background: Consistent with fulminant endothelial cell activation, elevated plasma von
Willebrand factor (VWF) antigen levels have been reported in patients with COVID-19. The
multimeric size and function of VWF are normally regulated through A Disintegrin And
Metalloprotease with ThrombSpondin Motif type 1 motif, member 13 (ADAMTS-13)--
mediated proteolysis. Objectives: This study investigated the hypothesis that ADAMTS-13
regulation of VWF multimer distribution may be impaired in severe acute respiratory …
Willebrand factor (VWF) antigen levels have been reported in patients with COVID-19. The
multimeric size and function of VWF are normally regulated through A Disintegrin And
Metalloprotease with ThrombSpondin Motif type 1 motif, member 13 (ADAMTS-13)--
mediated proteolysis. Objectives: This study investigated the hypothesis that ADAMTS-13
regulation of VWF multimer distribution may be impaired in severe acute respiratory …
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