Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy
Parkinson disease (PD) is the most common neurodegenerative movement disorder. An
increase in the amount of α-synuclein protein could constitute a cause of PD. α-Synuclein is
degraded at least partly by chaperone-mediated autophagy (CMA). The I93M mutation in
ubiquitin C-terminal hydrolase L1 (UCH-L1) is associated with familial PD. However, the
relationship between α-synuclein and UCH-L1 in the pathogenesis of PD has remained
largely unclear. In this study, we found that UCH-L1 physically interacts with LAMP-2A, the …
increase in the amount of α-synuclein protein could constitute a cause of PD. α-Synuclein is
degraded at least partly by chaperone-mediated autophagy (CMA). The I93M mutation in
ubiquitin C-terminal hydrolase L1 (UCH-L1) is associated with familial PD. However, the
relationship between α-synuclein and UCH-L1 in the pathogenesis of PD has remained
largely unclear. In this study, we found that UCH-L1 physically interacts with LAMP-2A, the …
以上显示的是最相近的搜索结果。 查看全部搜索结果