Ablation of undifferentiated human embryonic stem cells: exploiting innate immunity against the gal α1-3Galβ1-4GlcNAc-R (α-Gal) epitope
Z Hewitt, H Priddle, AJ Thomson, D Wojtacha… - Stem Cells, 2007 - academic.oup.com
… , undifferentiated ESCs, and germ cells [5]. We show that exposure of undifferentiated cells
to active human serum leads to cell … However, when exposure of the same cell line follows a …
to active human serum leads to cell … However, when exposure of the same cell line follows a …
Selective removal of undifferentiated embryonic stem cells from differentiation cultures through HSV1 thymidine kinase and ganciclovir treatment
… line that expresses a splice-corrected variant of the HSV1 thymidine kinase and eGFP
under the control of the Oct4 promoter for selective ablation of undifferentiated ES cells in vitro. …
under the control of the Oct4 promoter for selective ablation of undifferentiated ES cells in vitro. …
Laser-assisted photoablation of human pluripotent stem cells from differentiating cultures
S Terstegge, F Winter, BH Rath, I Laufenberg… - Stem Cell Reviews and …, 2010 - Springer
… the ablation of hPSC from differentiating cell … –gal epitope, leads to cell lysis of the engineered
hESC. The hTERT promoter is active in blastomeres, undifferentiated ESC and germ cells, …
hESC. The hTERT promoter is active in blastomeres, undifferentiated ESC and germ cells, …
Safeguarding clinical translation of pluripotent stem cells with suicide genes
W Li, AP Xiang - Organogenesis, 2013 - Taylor & Francis
… Identification and elimination of an immunodominant T-cell epitope in recombinant …
Neuron-like differentiation and selective ablation of undifferentiated embryonic stem cells …
Neuron-like differentiation and selective ablation of undifferentiated embryonic stem cells …
[HTML][HTML] Strategies to improve the safety of iPSC-derived β cells for β cell replacement in diabetes
S Pellegrini, V Zamarian, V Sordi - Transplant International, 2022 - frontierspartnerships.org
… , undifferentiated PSC can be identified by exploiting specific … for the ablation of hPSC from
differentiating cell cultures … prevented cell proliferation of residual undifferentiated stem cells …
differentiating cell cultures … prevented cell proliferation of residual undifferentiated stem cells …
[PDF][PDF] Genetic control of wayward pluripotent stem cells and their progeny after transplantation
M Kiuru, JL Boyer, TP O'Connor, RG Crystal - Cell stem cell, 2009 - cell.com
… prior to transplantation, enabling both tumor prevention and ablation … human tumors is to
utilize innate immunity against a(1,3)gal… exploited by appropriate design taking into account the …
utilize innate immunity against a(1,3)gal… exploited by appropriate design taking into account the …
Bioluminescence Imaging of Human Embryonic Stem Cells Transplanted In Vivo in Murine and Chick Models
H Priddle, A Grabowska, T Morris, PA Clarke… - … and stem cells, 2009 - liebertpub.com
… vivo imaging of cells transplanted into animal models. This is particularly relevant for human
embryonic stem cells (hESCs), because transplantation of undifferentiated hESCs leads to …
embryonic stem cells (hESCs), because transplantation of undifferentiated hESCs leads to …
[HTML][HTML] Embryonic stem cell-derived neural progenitors as non-tumorigenic source for dopaminergic neurons
MC Liao, M Diaconu, S Monecke… - … Journal of Stem Cells, 2014 - ncbi.nlm.nih.gov
… progenitor cell lines from human embryonic stem cells. METHODS: The human embryonic
stem (hES) cell line … stronger tumorigenic capacity than undifferentiated pluripotent stem cells. …
stem (hES) cell line … stronger tumorigenic capacity than undifferentiated pluripotent stem cells. …
Neural transplantation and stem cells
MS Rao, MC Vemuri - Neural Cell Transplantation: Methods and Protocols, 2009 - Springer
… other tissues or derived from embryonic stem cells (ESCs) have … it is known that the
undifferentiated stem cell state is unstable … Cells are selected based on cell surface epitopes using …
undifferentiated stem cell state is unstable … Cells are selected based on cell surface epitopes using …
Safeguarding pluripotent stem cells for cell therapy with a non-viral, non-integrating episomal suicide construct
… -formed tumors consisted mainly of undifferentiated cells with large nuclei, which appeared
… will function similarly in human embryonic stem cells and iPS cells. Since the episomal …
… will function similarly in human embryonic stem cells and iPS cells. Since the episomal …