This study is part of a comprehensive programme to investigate fluoride toxicity and the
hypothesis that fluoride ingested by 'medically compromised'animals will result in altered
physiological function. Its objectives were to monitor fluoride retention, tissue fluoride
concentrations and genetic variables in diabetic and control rats chronically exposed to
fluoride, and to determine whether or not adverse effects occurred. Male, Zucker fatty
diabetic rats and Zucker age-matched lean controls were fed a low-fluoride diet (< 1.2 …