Accessing the amide functionality by the mild and low-cost oxidation of imine
MA Mohamed, K Yamada, K Tomioka - Tetrahedron Letters, 2009 - Elsevier
Oxidation of imines using sodium chlorite under buffered conditions gave the corresponding
amides in good to high yield. The reaction was generally fast and was completed within 5–
40min. As has been established in the corresponding oxidation of aldehyde, so-called
Pinnick oxidation, the good functional group tolerance and the use of inexpensive reagents
are the advantages of this protocol.
amides in good to high yield. The reaction was generally fast and was completed within 5–
40min. As has been established in the corresponding oxidation of aldehyde, so-called
Pinnick oxidation, the good functional group tolerance and the use of inexpensive reagents
are the advantages of this protocol.
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