Activation of autophagy and suppression of apoptosis by dapagliflozin attenuates experimental inflammatory bowel disease in rats: Targeting AMPK/mTOR, HMGB1 …
HH Arab, MY Al-Shorbagy, MA Saad - Chemico-biological interactions, 2021 - Elsevier
Dapagliflozin, a selective sodium-glucose co-transporter 2 (SGLT2) inhibitor, has featured
marked anti-inflammatory effects in murine models of myocardial infarction, renal injury, and
neuroinflammation. Yet, its potential impact on the pathogenesis of inflammatory bowel
diseases (IBD) has not been previously investigated. The presented study aimed to explore
the prospect of dapagliflozin to mitigate 2, 4, 6 trinitrobenzene sulfonic acid (TNBS)-induced
rat colitis model which recapitulates several features of the human IBD. The molecular …
marked anti-inflammatory effects in murine models of myocardial infarction, renal injury, and
neuroinflammation. Yet, its potential impact on the pathogenesis of inflammatory bowel
diseases (IBD) has not been previously investigated. The presented study aimed to explore
the prospect of dapagliflozin to mitigate 2, 4, 6 trinitrobenzene sulfonic acid (TNBS)-induced
rat colitis model which recapitulates several features of the human IBD. The molecular …
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