The glial cytokine, interleukin-1β (IL-1β), potentiates the excitability of nociceptive trigeminal
ganglion (TRG) neurons via membrane depolarization following peripheral inflammation.
Perforated patch-clamp technique was used this study to show that the mechanism
underlying the excitability of small-diameter TRG neurons following inflammation is due to IL-
1β. Inflammation was induced by injection of complete Freund's adjuvant (CFA) into the
whisker pad. The TRG neurons innervating the site of inflammation were identified by …

Activation of Interleukin-1beta receptor suppresses the voltage-gated potassium currents in
the small-diameter trigeminal ganglion neurons following peripheral inflammation …
Activation of Interleukin-1beta receptor suppresses the voltage-gated potassium currents in
the small-diameter trigeminal ganglion neurons following peripheral inflammation …