Activation of mTORC1 by free fatty acids suppresses LAMP2 and autophagy function via ER stress in alcohol-related liver disease
Alcohol-related liver disease (ALD) is characterized by accumulation of hepatic free fatty
acids (FFAs) and liver injury. The present study aimed to investigate if mechanistic target of
rapamycin complex 1 (mTORC1) plays a role in FFA-induced organelle dysfunction, thereby
contributing to the development of ALD. Cell studies were conducted to define the causal
role and underlying mechanism of FFA-activated mTORC1 signaling in hepatocellular cell
injury. C57BL/6J wild-type mice were subjected to chronic alcohol feeding with or without …
acids (FFAs) and liver injury. The present study aimed to investigate if mechanistic target of
rapamycin complex 1 (mTORC1) plays a role in FFA-induced organelle dysfunction, thereby
contributing to the development of ALD. Cell studies were conducted to define the causal
role and underlying mechanism of FFA-activated mTORC1 signaling in hepatocellular cell
injury. C57BL/6J wild-type mice were subjected to chronic alcohol feeding with or without …
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