Active focal segmental glomerulosclerosis is associated with massive oxidation of plasma albumin
The basic mechanism for idiopathic FSGS still is obscure. Indirect evidence in humans and
generation of FSGS by oxidants in experimental models suggest a role of free radicals. In
vitro studies demonstrate a main role of plasma albumin as antioxidant, its modification
representing a chemical marker of oxidative stress. With the use of complementary liquid
chromatography electron spray ionization tandem mass spectrometry (LC-ESI-MS/MS) and
biochemical methods, plasma albumin was characterized in 34 patients with FSGS; 18 had …
generation of FSGS by oxidants in experimental models suggest a role of free radicals. In
vitro studies demonstrate a main role of plasma albumin as antioxidant, its modification
representing a chemical marker of oxidative stress. With the use of complementary liquid
chromatography electron spray ionization tandem mass spectrometry (LC-ESI-MS/MS) and
biochemical methods, plasma albumin was characterized in 34 patients with FSGS; 18 had …
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