Although substantial progress has been made in the diagnosis and treatment of acute
coronary syndromes, cardiovascular disease remains the leading cause of death globally, with …

The risk of acute coronary syndrome increases with age and is greater in men and in people
with a family history. However, other potentially modifiable risk factors—smoking, diabetes, …

… that we still have much to learn about the pathophysiology of the acute coronary syndromes.
… susceptible to rupture and precipitation of acute coronary syndromes. IFN-γ secreted by the …

… of atherosclerosis and in the acute coronary syndromes (Fig. 2 and 5), we shall now examine
the local and systemic factors present at the time of coronary plaque disruption that may …

Importance Acute coronary syndromes (ACS) are characterized by a sudden reduction in blood
supply to the heart and include ST-segment elevation myocardial infarction (STEMI), non-…

… The goal of this review was to propose a pathogenetic classification of acute coronary
syndromes that might help in the search of new diagnostic algorithms and therapeutic targets. …

… The pathogenesis of coronary artery disease and the acute coronary syndromes. Parts I
and II. … The pathogenesis of coronary artery disease and the acute coronary syndromes …

Figure 1: The established stable plaque. In this cross section of a human coronary artery there
is an established fibrolipid plaque with a core of lipid. The lipid core is separated from the …

Acute coronary syndrome (ACS) is a major health care and economic burden in the United
States and accounts for more than 1 million hospitalizations annually. The morbidity and …

… about the acute coronary syndromes. Today, we recognize that thrombosis underlies
most acute complications of atherosclerosis, notably unstable angina and acute myocardial …