Adherence and rehospitalizations in patients with schizophrenia: evidence from Japanese claims data
H Kuwabara, Y Saito, J Mahlich - Neuropsychiatric disease and …, 2015 - Taylor & Francis
H Kuwabara, Y Saito, J Mahlich
Neuropsychiatric disease and treatment, 2015•Taylor & FrancisBackground The aim of this study is to analyze if there is a relationship between adherence
to antipsychotic medication and rehospitalization for patients diagnosed with schizophrenia
in Japan. Methods Based on Japanese claims data, we constructed three patient groups
based on their medication possession ratio (MPR). Controlling for potential confounders, a
Cox proportional hazard model was employed to assess if medication adherence affects the
risk of rehospitalization. Results Patients with good adherence (MPRs from 0.8–1.1) had the …
to antipsychotic medication and rehospitalization for patients diagnosed with schizophrenia
in Japan. Methods Based on Japanese claims data, we constructed three patient groups
based on their medication possession ratio (MPR). Controlling for potential confounders, a
Cox proportional hazard model was employed to assess if medication adherence affects the
risk of rehospitalization. Results Patients with good adherence (MPRs from 0.8–1.1) had the …
Background
The aim of this study is to analyze if there is a relationship between adherence to antipsychotic medication and rehospitalization for patients diagnosed with schizophrenia in Japan.
Methods
Based on Japanese claims data, we constructed three patient groups based on their medication possession ratio (MPR). Controlling for potential confounders, a Cox proportional hazard model was employed to assess if medication adherence affects the risk of rehospitalization.
Results
Patients with good adherence (MPRs from 0.8–1.1) had the lowest rates of admission. Both poor adherence (MPRs <0.8) and overadherence (MPRs >1.1) were associated with a significant higher risk of rehospitalization with hazard ratios of 4.7 and 2.0, respectively.
Conclusion
The results of this study support the notion that good adherence to antipsychotic medication reduces the risk of rehospitalization of schizophrenia patients. Appropriate measures should be taken to improve adherence of schizophrenia patients.
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