Advances in molecular pathology and treatment of periampullary cancers
Pancreas, 2016•journals.lww.com
Objectives Periampullary cancers (PACs) include the following 4 traditional anatomic
subtypes: pancreatic, ampullary, biliary, or duodenal cancers. This review was performed to
highlight recent advances in the genomic and molecular understanding of each PAC
subtype and the advances in chemotherapeutic and molecular trials in these cancer
subtypes. Results Recent advances have highlighted differences in the genomic and
molecular features within each PAC subtype. Ampullary cancers can now be further defined …
subtypes: pancreatic, ampullary, biliary, or duodenal cancers. This review was performed to
highlight recent advances in the genomic and molecular understanding of each PAC
subtype and the advances in chemotherapeutic and molecular trials in these cancer
subtypes. Results Recent advances have highlighted differences in the genomic and
molecular features within each PAC subtype. Ampullary cancers can now be further defined …
Abstract
Objectives
Periampullary cancers (PACs) include the following 4 traditional anatomic subtypes: pancreatic, ampullary, biliary, or duodenal cancers. This review was performed to highlight recent advances in the genomic and molecular understanding of each PAC subtype and the advances in chemotherapeutic and molecular trials in these cancer subtypes.
Results
Recent advances have highlighted differences in the genomic and molecular features within each PAC subtype. Ampullary cancers can now be further defined accurately into their intestinal and pancreatobiliary subtypes using histomolecular profiling. K-ras mutation, which occurs in most pancreatic cancers, is found to occur less frequently in ampullary (42%–52%), biliary (22%–23%), and duodenal cancers (32%–35%), suggesting crucial differences in targetable mutations in these cancer subtypes.
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