An adjustable, louver-type wind barrier was introduced in this study for improving the running safety and ride comfort of train on the bridge under the undesirable wind environment. The aerodynamic characteristics of both train and bridge due to this novel wind barrier was systematically investigated based on the wind tunnel tests. It is suggested that rotation angles of the adjustable blade of the louver-type wind barrier should be controlled within to achieve an effective solution in terms of the overall aerodynamic performance of the train. Compared to the traditional grid-type wind barrier, the louver-type wind barrier generally presents better aerodynamic performance. Specifically, the larger decrease of the lift force and overturn moment of the train and the smaller increase of the drag force and torsional moment of the bridge resulting from the louver-type wind barrier were highlighted. Finally, the computational fluid dynamics (CFD) technique was applied to explore the underlying mechanism of aerodynamic control using the proposed wind barrier.