In this study, Ag@In₂O₃ modified nickel foam (NF) was reported for its role as a non-enzymatic glucose sensor. Ag@In₂O₃ was prepared by a simple two-step method; preparation of a metal-organic framework (MOF) MIL-68(In) by solvothermal method, entrapment of Ag + by adding AgNO₃ then drying it for 2 h to complete the entrapment process and subsequent calcination at 650°C for 3 h. The Ag@In₂O₃ modified NF was employed as a non-enzymatic glucose sensor to determine glucose concentrations in an alkaline medium. Two linear ranges were obtained from Ag@In₂O₃ modified electrode, i.e., 10 μM to 0.8 mM and 0.8–2.16 mM with a sensitivity of 3.31 mA mM⁻¹ cm⁻² and 1.51 mA mM⁻¹ cm⁻² respectively, with a detection limit of 0.49 µM. Ag@In₂O₃ modified NF exhibited high selectivity for glucose, among other interfering agents.