Aggregation of the diabetes-related peptide ProIAPP1-48 measured by dynamic light scattering
E Shardlow, C Rao, R Sattarov, L Wu, PE Fraser… - Journal of Trace …, 2019 - Elsevier
Abstract Islet amyloid polypeptide (IAPP 1-37) or amylin is implicated in the aetiology of
diabetes. It is found as amyloid along with its precursor ProIAPP 1-48 in the islets of
Langerhans in the pancreas. Metals have been implicated in amyloidogenesis of both IAPP
and ProIAPP. Herein we have used dynamic light scattering (DLS) to investigate how Al (III)
and Cu (II) influence aggregation of ProIAPP 1-48 under near-physiological conditions and
in a biologically-relevant timeframe. ProIAPP 1-48 formed primarily sub-micron particles …
diabetes. It is found as amyloid along with its precursor ProIAPP 1-48 in the islets of
Langerhans in the pancreas. Metals have been implicated in amyloidogenesis of both IAPP
and ProIAPP. Herein we have used dynamic light scattering (DLS) to investigate how Al (III)
and Cu (II) influence aggregation of ProIAPP 1-48 under near-physiological conditions and
in a biologically-relevant timeframe. ProIAPP 1-48 formed primarily sub-micron particles …
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