Aging as a consequence of misrepair--A novel theory of aging
J Wang, T Michelitsch, A Wunderlin, R Mahadeva - Nature Precedings, 2009 - nature.com
It is now increasingly realized that the underlying mechanisms which govern aging is a
complex interplay of genetic regulation and damage accumulation. Aging as a result of
accumulation of 'faults' on cellular and molecular levels, has been proposed in the damage
(fault)-accumulation theory by Kirkwood 2006. However, this theory fails to explain some
aging phenotypes such as fibrosis and premature aging, since terms such as 'damage'and
'fault'are not specified. Therefore we introduce here a specification of the underlying …
complex interplay of genetic regulation and damage accumulation. Aging as a result of
accumulation of 'faults' on cellular and molecular levels, has been proposed in the damage
(fault)-accumulation theory by Kirkwood 2006. However, this theory fails to explain some
aging phenotypes such as fibrosis and premature aging, since terms such as 'damage'and
'fault'are not specified. Therefore we introduce here a specification of the underlying …
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