Aldosterone stimulates its biosynthesis via a novel GPER-mediated mechanism
B Caroccia, TM Seccia, M Piazza… - The Journal of …, 2019 - academic.oup.com
Context The G protein–coupled estrogen receptor (GPER) mediates an aldosterone
secretagogue effect of 17 β-estradiol in human HAC15 adrenocortical cells after estrogen
receptor β blockade. Because GPER mediates mineralocorticoid receptor-independent
aldosterone effects in other cell types, we hypothesized that aldosterone could modulate its
own synthesis via GPER activation. Methods HAC15 cells were exposed to aldosterone in
the presence or absence of canrenone, a mineralocorticoid receptor antagonist, and/or of …
secretagogue effect of 17 β-estradiol in human HAC15 adrenocortical cells after estrogen
receptor β blockade. Because GPER mediates mineralocorticoid receptor-independent
aldosterone effects in other cell types, we hypothesized that aldosterone could modulate its
own synthesis via GPER activation. Methods HAC15 cells were exposed to aldosterone in
the presence or absence of canrenone, a mineralocorticoid receptor antagonist, and/or of …
[PDF][PDF] Aldosterone stimulates its biosynthesis via a novel GPER mediated mechanism
L Lenzini, G Pallafacchina… - Novel aspects of …, 2021 - cris.maastrichtuniversity.nl
Context: The G protein–coupled estrogen receptor (GPER) mediates an aldosterone
secretagogue effect of 17b-estradiol in human HAC15 adrenocortical cells after estrogen
receptor b blockade. Because GPER mediates mineralocorticoid receptor-independent
aldosterone effects in other cell types, we hypothesized that aldosterone could modulate its
own synthesis via GPER activation. Methods: HAC15 cells were exposed to aldosterone in
the presence or absence of canrenone, a mineralocorticoid receptor antagonist, and/or of …
secretagogue effect of 17b-estradiol in human HAC15 adrenocortical cells after estrogen
receptor b blockade. Because GPER mediates mineralocorticoid receptor-independent
aldosterone effects in other cell types, we hypothesized that aldosterone could modulate its
own synthesis via GPER activation. Methods: HAC15 cells were exposed to aldosterone in
the presence or absence of canrenone, a mineralocorticoid receptor antagonist, and/or of …
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