… to the S protein priming and cell entry of SARS-CoV-2 has yet to be determined, we
provide evidence that extracellular protease activity is rate-limiting in the process of SARS-CoV-2 …

… explore the mechanism underlying SARS-CoV-2 inhibition by α 1 AT. A recent preprint
publication suggests that α 1 AT may suppress TMPRSS2, the spike priming protease, similar to …

… serine proteases in SARS-CoV-2 infections and … limiting SARS-CoV-2 dissemination by
affecting the surface of the host cells. SummaryDelivery of extracellular serine protease inhibitors …

… Because alpha-1-antitrypsin (AAT) embraces a panoply of … mechanisms induced by
SARS-CoV-2, we hypothesize that this … protease inhibitor (SERPIN) shown to inhibit TMPRSS-2, …

… that AAT inhibits cell surface transmembrane protease 2 (TMPRSS2) — a host serine protease
required for SARS-CoV-2 entry into cells — and that this inhibition may be augmented by …

… TMPRSS2 is essential for SARS-CoV-2-S protein priming … In this study, the proteinase
inhibitor attenuated HIV replication … can inhibit the TMPRSS2-mediated SARS-CoV-2 infection, …

… inhibitor of the spike priming protease TMPRSS2 was included as control 9,12 . α1-AT and
CM both suppressed SARS-CoV-2 … cells, with half-maximal inhibitory concentrations (IC 50 ) …

… , and authentic SARS-CoV-2, we show that AAT inhibition occurs at … protein could inhibit
TMPRSS2-mediated SARS-CoV-2 entry. … alpha-1 antitrypsin as the primary inhibitor of protease-…

… serine protease Transmembrane Protease 2 (TMPRSS2) … inhibition of both TMPRSS2
and coronavirus infection. Such host-directed therapy is less likely to be affected by SARS-CoV-2 …

… , and authentic SARS-CoV-2, we show that AAT inhibition occurs at … protein could inhibit
TMPRSS2-mediated SARS-CoV-2 entry. … alpha-1 antitrypsin as the primary inhibitor of protease-…