Alterations of atrial electrophysiology related to hemodialysis session: insights from a multiscale computer model
BACKGROUND: The prevalence of atrial fibrillation is increased in patients with end-stage
renal disease. Previous studies suggested that extracellular electrolyte alterations caused
by hemodialysis (HD) therapy could be proarrhythmic. METHODS: Multiscale models were
used for a consequent analysis of the effects of extracellular ion concentration changes on
atrial electrophysiology. Simulations were based on measured electrolyte concentrations
from patients with end-stage renal disease. RESULTS: Simulated conduction velocity and …
renal disease. Previous studies suggested that extracellular electrolyte alterations caused
by hemodialysis (HD) therapy could be proarrhythmic. METHODS: Multiscale models were
used for a consequent analysis of the effects of extracellular ion concentration changes on
atrial electrophysiology. Simulations were based on measured electrolyte concentrations
from patients with end-stage renal disease. RESULTS: Simulated conduction velocity and …