Altered G1 checkpoint control determines adaptive survival responses to ionizing radiation
DA Boothman, M Meyers, E Odegaard… - … and Molecular Mechanisms …, 1996 - Elsevier
Adaptive survival responses (ASRs) are observed when cells become more resistant to a
high dose of a cytotoxic agent after repeated low dose exposures to that agent or another
genotoxic agent. Confluent (G 0G 1) human normal (GM2936B, GM2937A, AG2603, IMR-
90), cancer-prone (XPV2359), and neoplastic (U1-Mel, HEp-2, HTB-152) cells were primed
with repeated low doses of X-rays (ranging from 0.05–10 cGy/day for 4 days), then
challenged with a high dose (290–450 cGy) on day 5. U1-Mel and HEp-2 cells showed …
high dose of a cytotoxic agent after repeated low dose exposures to that agent or another
genotoxic agent. Confluent (G 0G 1) human normal (GM2936B, GM2937A, AG2603, IMR-
90), cancer-prone (XPV2359), and neoplastic (U1-Mel, HEp-2, HTB-152) cells were primed
with repeated low doses of X-rays (ranging from 0.05–10 cGy/day for 4 days), then
challenged with a high dose (290–450 cGy) on day 5. U1-Mel and HEp-2 cells showed …
以上显示的是最相近的搜索结果。 查看全部搜索结果