Ameliorative effect of caffeic acid against inflammatory pain in rodents
A Mehrotra, R Shanbhag, MR Chamallamudi… - European Journal of …, 2011 - Elsevier
The present study was designed to evaluate the antinociceptive profile of caffeic acid in mice
and rats. Caffeic acid (5–100 mg/kg, po), in a dose dependent manner inhibited acetic acid-
induced writhing and late phase of formalin-induced pain in mice, with an ED 50 of 22.38
and 10.92 mg/kg, respectively. However, caffeic acid was ineffective in the hot plate and tail
flick tests. Analgesic activity was also examined in carrageenan and lipopolysaccharide
(LPS)-induced mechanical hyperalgesia in rats, where locally induced myeloperoxidase …
and rats. Caffeic acid (5–100 mg/kg, po), in a dose dependent manner inhibited acetic acid-
induced writhing and late phase of formalin-induced pain in mice, with an ED 50 of 22.38
and 10.92 mg/kg, respectively. However, caffeic acid was ineffective in the hot plate and tail
flick tests. Analgesic activity was also examined in carrageenan and lipopolysaccharide
(LPS)-induced mechanical hyperalgesia in rats, where locally induced myeloperoxidase …
Ameliorative effect of caffeic acid against inflammatory pain in rodents.
AM Anurag Mehrotra, RS Ravindranath Shanbhag… - 2011 - cabidigitallibrary.org
The present study was designed to evaluate the antinociceptive profile of caffeic acid in mice
and rats. Caffeic acid (5-100 mg/kg, po), in a dose dependent manner inhibited acetic acid-
induced writhing and late phase of formalin-induced pain in mice, with an ED50 of 22.38
and 10.92 mg/kg, respectively. However, caffeic acid was ineffective in the hot plate and tail
flick tests. Analgesic activity was also examined in carrageenan and lipopolysaccharide
(LPS)-induced mechanical hyperalgesia in rats, where locally induced myeloperoxidase …
and rats. Caffeic acid (5-100 mg/kg, po), in a dose dependent manner inhibited acetic acid-
induced writhing and late phase of formalin-induced pain in mice, with an ED50 of 22.38
and 10.92 mg/kg, respectively. However, caffeic acid was ineffective in the hot plate and tail
flick tests. Analgesic activity was also examined in carrageenan and lipopolysaccharide
(LPS)-induced mechanical hyperalgesia in rats, where locally induced myeloperoxidase …
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