Amiodarone biokinetics, the formation of its major oxidative metabolite and neurotoxicity after acute and repeated exposure of brain cell cultures
The difficulty in mimicking nervous system complexity and cell–cell interactions as well as
the lack of kinetics information has limited the use of in vitro neurotoxicity data. Here, we
assessed the biokinetic profile as well as the neurotoxicity of Amiodarone after acute and
repeated exposure in two advanced rodent brain cell culture models, consisting of both
neurons and glial cells organized in 2 or 3 dimensions to mimic the brain histiotypic structure
and function. A strategy was applied to evidence the abiotic processes possibly affecting …
the lack of kinetics information has limited the use of in vitro neurotoxicity data. Here, we
assessed the biokinetic profile as well as the neurotoxicity of Amiodarone after acute and
repeated exposure in two advanced rodent brain cell culture models, consisting of both
neurons and glial cells organized in 2 or 3 dimensions to mimic the brain histiotypic structure
and function. A strategy was applied to evidence the abiotic processes possibly affecting …
[PDF][PDF] Amiodarone biokinetics, the formation of its major oxidative metabolite
abstract 31 The difficulty in mimicking nervous system complexity and cell–cell interactions
as well as the lack of 32 kinetics information has limited the use of in vitro neurotoxicity data.
33 Here, we assessed the biokinetic profile as well as the neurotoxicity of Amiodarone after
acute and 34 repeated exposure in two advanced rodent brain cell culture models,
consisting of both neurons and glial 35 cells organized in 2 or 3 dimensions to mimic the
brain histiotypic structure and function. A strategy was 36 applied to evidence the abiotic …
as well as the lack of 32 kinetics information has limited the use of in vitro neurotoxicity data.
33 Here, we assessed the biokinetic profile as well as the neurotoxicity of Amiodarone after
acute and 34 repeated exposure in two advanced rodent brain cell culture models,
consisting of both neurons and glial 35 cells organized in 2 or 3 dimensions to mimic the
brain histiotypic structure and function. A strategy was 36 applied to evidence the abiotic …
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