… research suggest that physiologic generation of the neurotoxic Aβ peptide from sequential
amyloid precursor protein (… APP is a single-pass transmembrane protein expressed at high …

… composed of hyperphosphorylated tau protein. Aβ is generated by proteolytic processing
of the β-amyloid precursor protein (APP). Most individuals with Down syndrome (DS) have …

… against the full-length amyloid precursor protein of Alzheimer's disease (APP695), revealed
… from Alzheimer patients compared with controls. Purified platelet amyloid precursor proteins …

… Several treatment options for AD are under investigation, including antibody-based
therapy and stem cell transplantation. Amyloid precursor protein (APP) is a membrane protein …

… amyloid precursor protein, and on the central role of amyloid in the pathogenesis of Alzheimer’s
disease… processing from the much larger amyloid precursor protein (APP) has led to …

In this review, we argue that at least one insult that causes Alzheimer’s disease (AD) is
disruption of the normal function of the amyloid precursor protein (APP). Familial Alzheimer’s …

… This article reviews studies on the structure, expression and post-translational processing
of β-amyloid precursor protein (APP), as well as studies on the effects of APP in vitro and in …

… peptide was cloned and sequenced 2 it was found to encode a protein that is much larger …
larger protein, called the amyloid precursor protein (APP). APP is a large, multidomain protein …

… Many models of disease progression in Alzheimer’s disease (AD) have been proposed to …
amyloid cascade (ACH) and presenilin (PSH) hypotheses and the amyloid precursor protein (…

… chronic neurologic diseases. The amyloid precursor protein (APP) of Alzheimer's disease or
… Thus, copper-mediated toxicity may contribute to neurodegeneration in Alzheimer's disease…