An RNA modification with remarkable resistance to RNase A
A Ghidini, C Ander, A Winqvist… - Chemical …, 2013 - pubs.rsc.org
A Ghidini, C Ander, A Winqvist, R Strömberg
Chemical Communications, 2013•pubs.rsc.orgA 3′-deoxy-3′-C-methylenephosphonate modified diribonucleotide is highly resistant to
degradation by spleen phosphodiesterase and not cleaved at all by snake venom
phosphodiesterase. The most remarkable finding is that, despite the fact that both the vicinal
2-hydroxy nucleophile and the 5′-oxyanion leaving group are intact, the 3′-
methylenephosponate RNA modification is also highly resistant towards the action of RNase
A.
degradation by spleen phosphodiesterase and not cleaved at all by snake venom
phosphodiesterase. The most remarkable finding is that, despite the fact that both the vicinal
2-hydroxy nucleophile and the 5′-oxyanion leaving group are intact, the 3′-
methylenephosponate RNA modification is also highly resistant towards the action of RNase
A.
A 3′-deoxy-3′-C-methylenephosphonate modified diribonucleotide is highly resistant to degradation by spleen phosphodiesterase and not cleaved at all by snake venom phosphodiesterase. The most remarkable finding is that, despite the fact that both the vicinal 2-hydroxy nucleophile and the 5′-oxyanion leaving group are intact, the 3′-methylenephosponate RNA modification is also highly resistant towards the action of RNase A.
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