This study aims to analyse healthcare personnel’s anxiety levels during the COVID-19 pandemic in terms of their psychological resilience and the problems they experienced. The study was carried out with the relational screening model. The sample of the study consisted of 411 healthcare personnel working in various hospitals in Turkey (physicians, nurses, midwives, dentists, pharmacists, emergency medical/surgical technicians, social workers, psychologists, dieticians, paramedics, laboratory workers, medical secretaries, etc.). A personal information form, the Beck Anxiety Inventory (BAI), and the Connor-Davidson Resilience Scale (CD-RISC) were used to collect data. In the analysis of the data, Pearson's Product-Moment Correlation, Hierarchical Multiple Regression Analysis were used for descriptive statistics. The study results indicated that healthcare personnel had a moderate level of anxiety (= 17.25 and ss= 14.81) and that being female, showing the symptoms of COVID-19, having difficulty concentrating, physical fatigue, inability to obtain adequate protective equipment, being excluded due to the concern of transmitting the virus, and having problems in communicating with their spouse/partner positively predicted the healthcare personnel’s anxiety levels. On the other hand, the inability to maintain their previous social life and a high psychological resilience level negatively predicted the healthcare personnel’s anxiety levels, and the model explained 57.3% of the total variance. Based on these results, it is recommended that preventive developmental mental health interventions be planned and carried out with an interdisciplinary team to reduce healthcare personnel’s anxiety levels.