An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses
The devastation caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has made clear the importance of pandemic preparedness. To address future zoonotic
outbreaks due to related viruses in the sarbecovirus subgenus, we identified a human
monoclonal antibody, 10-40, that neutralized or bound all sarbecoviruses tested in vitro and
protected against SARS-CoV-2 and SARS-CoV in vivo. Comparative studies with other
receptor-binding domain (RBD)–directed antibodies showed 10-40 to have the greatest …
has made clear the importance of pandemic preparedness. To address future zoonotic
outbreaks due to related viruses in the sarbecovirus subgenus, we identified a human
monoclonal antibody, 10-40, that neutralized or bound all sarbecoviruses tested in vitro and
protected against SARS-CoV-2 and SARS-CoV in vivo. Comparative studies with other
receptor-binding domain (RBD)–directed antibodies showed 10-40 to have the greatest …
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