An appraisal of cinnamyl sulfonamide hydroxamate derivatives (HDACáinhibitors) for anti-cancer, anti-angiogenic and anti-metastatic activities in human cancer cells
Multiple genetic mutations along with unusual epigenetic modifications play a major role in
cancer development. Histone deacetylase (HDAC) enzyme overexpression observed in the
majority of cancers is responsible for tumor suppressor gene silencing and activation of
proto-oncogenes to oncogenes. Cinnamic acid derivatives exhibit anti-cancer potential
through HDAC enzyme inhibition. We have synthesized a few cinnamyl sulfonamide
hydroxamate derivatives (NMJ-1,-2 and-3) by already published in-house procedures and …
cancer development. Histone deacetylase (HDAC) enzyme overexpression observed in the
majority of cancers is responsible for tumor suppressor gene silencing and activation of
proto-oncogenes to oncogenes. Cinnamic acid derivatives exhibit anti-cancer potential
through HDAC enzyme inhibition. We have synthesized a few cinnamyl sulfonamide
hydroxamate derivatives (NMJ-1,-2 and-3) by already published in-house procedures and …