An asymmetric synthesis of Levetiracetam

V Raju, S Somaiah, S Sashikanth, E Laxminarayana… - 2014 - nopr.niscpr.res.in
… In conclusion, we achieved an asymmetric synthesis of (S)-levetiracetam by means of an
asymmetric Strecker reaction, which involves the chemical reaction from most economically …

[PDF][PDF] Asymmetric synthesis of the antiepileptic drug levetiracetam

T Imahori, K Omoto, Y Hirose… - …, 2008 - triggered.edina.clockss.org
asymmetric synthesis. 3 As a part of our ongoing interest in synthesis of biologically important
… based on palladium-catalyzed asymmetric allylic alkylation, 4 we describe an asymmetric

Enantioselective Synthesis of Antiepileptic Drug: (‐)‐Levetiracetam—Synthetic Applications of the Versatile New Chiral N‐Sulfinimine

K Chandra Babu, R Buchi Reddy, E Naresh… - Journal of …, 2013 - Wiley Online Library
… We report an asymmetric synthesis of (-)-Levetiracetam (1) in six steps starting from versatile
new chiral N-… Subsequent reactions yielded the targeted compound levetiracetam (1). …

Enantioselective Synthesis of Antiepileptic Agent,(−)‐Levetiracetam, through Evans Asymmetric Strategy

K Chandra Babu, R Buchi Reddy… - Journal of …, 2013 - Wiley Online Library
… In this paper, we report a practical and efficient enantio selective synthesis of levetiracetam,
1, in five steps with good overall yield using Evans type asymmetric α-alkylation of …

[PDF][PDF] Levetiracetam analogs: chemoenzymatic synthesis, absolute configuration assignment and evaluation of cholinesterase inhibitory activities

CD de Freitas Milagre, BS do Amaral, JMB Junior… - Eclética …, 2022 - redalyc.org
… active pharmaceutical ingredients, with the aim of making organic synthesis greener (Bisogno …
Commercially, levetiracetam is currently produced via a chemoenzymatic process, where …

[PDF][PDF] An efficient and stereoselective synthesis of Levetiracetam: An anticonvulsant drug

V Raju, S Somaiah, S Sashikanth… - Drug Invention …, 2014 - researchgate.net
synthesis for the preparation of levetiracetam has been achieved by the asymmetric … Now
the key step in our synthesis is the asymmetric alkylation of compound 6 with ethyl bromide in …

Novel levetiracetam derivatives that are effective against the Alzheimer-like phenotype in mice: synthesis, in vitro, ex vivo, and in vivo efficacy studies

I Sola, E Aso, D Frattini, I Lopez-Gonzalez… - Journal of medicinal …, 2015 - ACS Publications
… We have synthesized a series of heptamethylene-linked levetiracetam–huprine and
levetiracetam–(… The levetiracetam–huprine hybrid 10 significantly reduced the incidence of …

The sustainable synthesis of levetiracetam by an enzymatic dynamic kinetic resolution and an ex-cell anodic oxidation

S Arndt, B Grill, H Schwab, G Steinkellner… - Green …, 2021 - pubs.rsc.org
Levetiracetam is an active pharmaceutical ingredient widely used to treat epilepsy. We describe
a new synthesis of levetiracetam by a … For the subsequent oxidation to levetiracetam, we …

Theoretical studies on racemization of levetiracetam: Structural movements, character of hydroxide ion and guidelines for efficient control

Z Li, C Wu, J Liu, L Li, C Sun, T Sun - Journal of Molecular Liquids, 2019 - Elsevier
… focused on the stereochemistry of levetiracetam during synthesis. However, unexpected …
mechanism for levetiracetam. In this article, the racemization process for levetiracetam is …

Synthetic approaches toward the synthesis of Brivaracetam: An antiepileptic drug

M Gayke, H Narode, G Eppa, RS Bhosale… - ACS omega, 2022 - ACS Publications
… to synthesize in several ways such as through exercising enzymatic resolution, chiral pool
synthesis, and asymmetric synthesis. … Usually, brivaracetam and levetiracetam bind with the …