过去一年中添加的文章，按日期排序
Small molecule inhibitors of the VEGF and tyrosine kinase for the treatment of cervical cancer
F Sarwar, S Ashhad, A Vimal, R Vishvakarma - Medical Oncology, 2024 - Springer
2 天前 - … This review paper highlights the genesis of cervical cancer … small molecule
inhibitors inhibit intracellular signaling by attaching to catalytic sites where ATP binds in VEGFR's …
inhibitors inhibit intracellular signaling by attaching to catalytic sites where ATP binds in VEGFR's …
Small Molecule Therapeutics in the Pipeline Targeting for Triple-Negative Breast Cancer: Origin, Challenges, Opportunities, and Mechanisms of Action
35 天前 - … This review will shed light on the molecular characterization of TNBC, single drug
targets, … receptor that regulates VEGF signaling. The binding of VEGF to VEGFR-2 causes the …
targets, … receptor that regulates VEGF signaling. The binding of VEGF to VEGFR-2 causes the …
Advances of VEGF signalling pathway in hepatocellular carcinomar invasion and metastasis and therapy
X LAN, Y HUANG, M ZHU, P MA… - Chinese Journal of …, 2024 - manu41.magtech.com.cn
53 天前 - … Monoclonal antibodies against VEGF and small-molecule tyrosine kinase inhibitors
… This article provides a review of the research progress of VEGF/VEGFR inhibitors in HCC …
… This article provides a review of the research progress of VEGF/VEGFR inhibitors in HCC …
[HTML][HTML] From Tumor to Bone: Growth Factor Receptors as Key Players in Cancer Metastasis
KS Mohammad, SA Akhund - Frontiers in Bioscience-Landmark, 2024 - imrpress.com
60 天前 - … the VEGF/VEGFR, EGF/EGFR, FGF/FGFR, and TGF β /TGF β R pathways. These
include a variety of compounds, such as small molecule inhibitors … underlying VEGF signaling, …
include a variety of compounds, such as small molecule inhibitors … underlying VEGF signaling, …
BB5523, a multiple kinase inhibitor with HPK1, VEGFR2 and TNIK inhibition, enhanced antitumor immunity in tumor models
G Duan, M Li, P Zhang, W Hua, E Hao, S Wang, X Ma… - Cancer Research, 2024 - AACR
112 天前 - … VEGF/VEGFR2 pathway is the central … small molecule kinase inhibitor, BB5523
boosts anti-tumor immunity through HPK1 inhibition, while also blocking crucial signaling …
boosts anti-tumor immunity through HPK1 inhibition, while also blocking crucial signaling …
Recent development of VEGFR small molecule inhibitors as anticancer agents: A patent review (2021–2023)
J Zeng, Q Deng, Z Chen, S Yan, Q Dong, Y Zhang… - Bioorganic …, 2024 - Elsevier
125 天前 - … In recent years, many small molecule inhibitors targeting VEGFR … Here, we provide
an overview of the structure and … Therefore, the VEGF/VEGFR-2 signaling cascade is an …
an overview of the structure and … Therefore, the VEGF/VEGFR-2 signaling cascade is an …
Exploring Small-Molecule Inhibitors Targeting MAPK Pathway Components: Focus on ERK, MEK1, and MEK2 Kinases in Cancer Treatment
T Mukherjee, S Mohanty, J Kaur, M Das… - Chemical Biology …, 2024 - pubs.thesciencein.org
141 天前 - … will review the present state of MAPK pathway inhibitors, … This study will examine
the ERK signaling pathway in both … growth factor or VEGF while suppressing prohibitor …
the ERK signaling pathway in both … growth factor or VEGF while suppressing prohibitor …
Structure–Activity Relationship Study and Design Strategies of Hydantoin, Thiazolidinedione, and Rhodanine-Based Kinase Inhibitors: A Two-Decade Review
174 天前 - … The alteration of cell signaling enzymes, such as kinases, … discoveries of small-molecule
kinase inhibitors (SMKIs); … , serve as crucial pharmacophores in VEGFR inhibitors, as …
kinase inhibitors (SMKIs); … , serve as crucial pharmacophores in VEGFR inhibitors, as …
Pyrrolo [2, 3-d] pyrimidines as EGFR and VEGFR kinase inhibitors: a comprehensive SAR review.
K Metwally, NE Abo-Dya - Current Medicinal Chemistry, 2023 - europepmc.org
331 天前 - … of cellular physiological processes, including cell signaling. The discovery of the …
small molecule chemical entities of diverse structural backgrounds as tyrosine kinase inhibitors …
small molecule chemical entities of diverse structural backgrounds as tyrosine kinase inhibitors …
[HTML][HTML] In Silico evaluation of HN-N07 small molecule as an inhibitor of Angiogenesis and Lymphangiogenesis Oncogenic signatures in Non-small Cell Lung Cancer
LC Chen, N Mokgautsi, YC Kuo, ATH Wu, HS Huang - Biomedicines, 2023 - mdpi.com
361 天前 - … summary, these results indicate that HN-N07 shows promise as a potential inhibitor
of oncogenic signaling … Therefore, exploring the inhibition of the VEGFR/FLT4 pathway may …
of oncogenic signaling … Therefore, exploring the inhibition of the VEGFR/FLT4 pathway may …