An update on immune dysregulation in obesity‐related insulin resistance
G Daryabor, D Kabelitz… - Scandinavian journal of …, 2019 - Wiley Online Library
G Daryabor, D Kabelitz, K Kalantar
Scandinavian journal of immunology, 2019•Wiley Online LibraryObesity is associated with chronic low‐grade inflammation of the adipose tissue (AT) that
might develop into systemic inflammation, insulin resistance (IR) and an increased risk of
type 2 diabetes mellitus (T2DM) in severe obese rodents and humans. In the lean state,
small normal adipocytes and AT macrophages interact with each other to maintain metabolic
homeostasis but during obesity, enlarged adipocytes secrete inflammatory mediators and
express immune receptors to recruit immune cells and aggravate the inflammation. The …
might develop into systemic inflammation, insulin resistance (IR) and an increased risk of
type 2 diabetes mellitus (T2DM) in severe obese rodents and humans. In the lean state,
small normal adipocytes and AT macrophages interact with each other to maintain metabolic
homeostasis but during obesity, enlarged adipocytes secrete inflammatory mediators and
express immune receptors to recruit immune cells and aggravate the inflammation. The …
Abstract
Obesity is associated with chronic low‐grade inflammation of the adipose tissue (AT) that might develop into systemic inflammation, insulin resistance (IR) and an increased risk of type 2 diabetes mellitus (T2DM) in severe obese rodents and humans. In the lean state, small normal adipocytes and AT macrophages interact with each other to maintain metabolic homeostasis but during obesity, enlarged adipocytes secrete inflammatory mediators and express immune receptors to recruit immune cells and aggravate the inflammation. The better understanding of the obesity‐related inflammatory milieu and the sequential events leading to IR could be helpful in designing new preventive and therapeutic strategies. The present review will discuss the cellular and molecular abnormalities participating in the pathogenesis of obesity in obese individuals as well as high‐fat diet (HFD)‐fed mice, a mouse model of obesity.
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