The aim of this paper is to investigate the energetic and exergic performance of the close loop radiant cooling panel system using mathematical modeling. In this study, efforts have been made to determine the COP, cooling capacity and second law efficiency of radiant panel at different operating parameters. Based on results, it is found that mass flow rate of heat carrying fluid plays a major role as compared to plate thickness and pipe thermal conductivity in the thermal performance radiant panel system. The increase in mass flow rate of circulating fluid from 0.01 kg/s to 0.04 kg/s leads to increase the cooling capacity of the radiant panel around 20.9%. Whereas the reduction in inlet temperature of 22% increases the rate of heat transfer to around 62% and the maximum COP is observed as 2.26 at 0.01 kg/s. Further, COP of the panel is found to increase with the increase in plate thickness and with the increase in inlet fluid temperature the exergy of the panel reduces.