Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity
The purpose of this review paper is to present evidence that rat animal models of alcoholism
provide an ideal platform for developing and screening medications that target alcohol
abuse and dependence. The focus is on the 5 oldest international rat lines that have been
selectively bred for a high alcohol-consumption phenotype. The behavioral and
neurochemical phenotypes of these rat lines are reviewed and placed in the context of the
clinical literature. The paper presents behavioral models for assessing the efficacy of …
provide an ideal platform for developing and screening medications that target alcohol
abuse and dependence. The focus is on the 5 oldest international rat lines that have been
selectively bred for a high alcohol-consumption phenotype. The behavioral and
neurochemical phenotypes of these rat lines are reviewed and placed in the context of the
clinical literature. The paper presents behavioral models for assessing the efficacy of …
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