Efferocytosis is believed to be a key regulator for lung inflammation in chronic obstructive
pulmonary disease. In this study we pharmacologically inhibited efferocytosis with annexin V
and attempted to determine its impact on the progression of pulmonary emphysema in
mouse. We first demonstrated in vitro and in vivo efferocytosis experiments using annexin V,
an inhibitor for phosphatidylserine-mediated efferocytosis. We then inhibited efferocytosis in
porcine pancreatic elastase (PPE)-treated mice. PPE-treated mice were instilled annexin V …

CiNii 博士論文 - Annexin Ⅴ decreases PS-mediated macrophage efferocytosis and
deteriorates elastase-induced pulmonary emphysema in mice … Annexin Ⅴ decreases PS-mediated
macrophage efferocytosis and deteriorates elastase-induced pulmonary emphysema in mice
アネキシンⅤを用いたマクロファージによるPSを介したエフェロサイトーシスの減弱化とエラスターゼ
誘導マウス肺気腫の悪化の検討 … Annexin Ⅴ decreases PS-mediated macrophage
efferocytosis and deteriorates elastase-induced pulmonary emphysema in mice …