[HTML][HTML] Anti-PF4 VITT antibodies are oligoclonal and variably inhibited by heparin
B Singh, A Kanack, A Bayas, G George… - medRxiv, 2021 - ncbi.nlm.nih.gov
Background COVID-19 vaccines have been associated with a rare thrombotic and
thrombocytopenic reaction, Vaccine-induced immune thrombotic thrombocytopenia (VITT)
characterized by platelet-activating anti-PF4 antibodies. This study sought to assess
clonality of VITT antibodies and evaluate their characteristics in antigen-based and
functional platelet studies. Methods Anti-PF4 antibodies were isolated from five patients with
VITT secondary to ChAdOx1 nCoV-19 (n= 1) or Ad26. COV2. S (n= 4) vaccination. For …
thrombocytopenic reaction, Vaccine-induced immune thrombotic thrombocytopenia (VITT)
characterized by platelet-activating anti-PF4 antibodies. This study sought to assess
clonality of VITT antibodies and evaluate their characteristics in antigen-based and
functional platelet studies. Methods Anti-PF4 antibodies were isolated from five patients with
VITT secondary to ChAdOx1 nCoV-19 (n= 1) or Ad26. COV2. S (n= 4) vaccination. For …
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