Anti-inflammatory activity of Calophyllum inophyllum fruits extracts

MB Zakaria, Z Ilham, NA Muhamad - Procedia chemistry, 2014 - Elsevier
MB Zakaria, Z Ilham, NA Muhamad
Procedia chemistry, 2014Elsevier
In the present work, we are reporting the isolation. characterisation and bioactvity of
inophyllums, xanthones and other compounds found in the fruits of Callophyllum
inophyllum. In-vitro assays demonstrated that the crude extract at concentration of 50 μg/ml
inhibited 77% and 88% cyclooxygenase and lipooxygenase activities, respectively,
indicating its potential as anti-inflamatory agent. Phytochemical studies was also conducted
on the fruits. Inophyllum A, inophyllum C, inophyllum E, calophylloide, calophynic acid, 11 …
Abstract
In the present work, we are reporting the isolation. characterisation and bioactvity of inophyllums, xanthones and other compounds found in the fruits of Callophyllum inophyllum. In-vitro assays demonstrated that the crude extract at concentration of 50 μg/ml inhibited 77% and 88% cyclooxygenase and lipooxygenase activities, respectively, indicating its potential as anti-inflamatory agent. Phytochemical studies was also conducted on the fruits. Inophyllum A, inophyllum C, inophyllum E, calophylloide, calophynic acid, 11,12-anhydroinophyllum A, 1,7-dihydroxy-6-methoxyxanthone, potocatechuic acid, gallic acid, n-nonacosane, β-sitosterol and sitosterol-3-O-β-D-glucopyranoside were isolated and idetified. On the HPLC chromatogram, at least 18 compounds can be detected.
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