[HTML][HTML] Antibody upstream sequence diversity and its biological implications revealed by repertoire sequencing
Y Zhu, X Yang, C Ma, H Tang, Q Wang, J Guan… - Journal of Genetics and …, 2021 - Elsevier
The sequence upstream of the antibody variable region (antibody upstream sequence
[AUS]) consists of a 5′ untranslated region (5′ UTR) and a preceding leader region. The
sequence variations in AUS affect antibody engineering and PCR based antibody
quantification and may also be implicated in mRNA transcription and translation. However,
the diversity of AUSs remains elusive. Using 5′ rapid amplification of cDNA ends and high-
throughput antibody repertoire sequencing technique, we acquired full-length AUSs for …
[AUS]) consists of a 5′ untranslated region (5′ UTR) and a preceding leader region. The
sequence variations in AUS affect antibody engineering and PCR based antibody
quantification and may also be implicated in mRNA transcription and translation. However,
the diversity of AUSs remains elusive. Using 5′ rapid amplification of cDNA ends and high-
throughput antibody repertoire sequencing technique, we acquired full-length AUSs for …
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