Anticancer potential of docetaxel-loaded cobalt ferrite nanocarrier: an in vitro study on MCF-7 and MDA-MB-231 cell lines
Journal of microencapsulation, 2021•Taylor & Francis
Aim To develop a biocompatible cobalt ferrite (CF-NP) nanodrug formulation using oleic
acid and poly (d, l-lactide-co-glycolic) acid (PLGA) for the delivery of docetaxel (DTX)
specifically to breast cancer cells. Methods The CF-NP were synthesised by hydrothermal
method and conjugated with DTX in a PLGA matrix and were systematically characterised
using XRD, FE-SEM, TEM, DLS, FTIR, TGA, SQUID etc. The drug loading, in vitro drug
release, cellular uptake, cytotoxicity were evaluated and haemolytic effect was studied …
acid and poly (d, l-lactide-co-glycolic) acid (PLGA) for the delivery of docetaxel (DTX)
specifically to breast cancer cells. Methods The CF-NP were synthesised by hydrothermal
method and conjugated with DTX in a PLGA matrix and were systematically characterised
using XRD, FE-SEM, TEM, DLS, FTIR, TGA, SQUID etc. The drug loading, in vitro drug
release, cellular uptake, cytotoxicity were evaluated and haemolytic effect was studied …
Aim
To develop a biocompatible cobalt ferrite (CF-NP) nanodrug formulation using oleic acid and poly (d,l-lactide-co-glycolic) acid (PLGA) for the delivery of docetaxel (DTX) specifically to breast cancer cells.
Methods
The CF-NP were synthesised by hydrothermal method and conjugated with DTX in a PLGA matrix and were systematically characterised using XRD, FE-SEM, TEM, DLS, FTIR, TGA, SQUID etc. The drug loading, in vitro drug release, cellular uptake, cytotoxicity were evaluated and haemolytic effect was studied.
Results
The CF-NP showed good crystallinity with an average particle size of 21 nm and ferromagnetic nature. The DTX-loaded CF-NP (DCF-NP) showed 8.4% (w/w) drug loading with 81.8% loading efficiency with a sustained DTX release over time. An effective internalisation and anti-proliferative efficiency was observed in MCF-7 and MDA-MB-231 breast cancer cells and negligible haemolytic effect.
Conclusion
The DCF-NP can have the potential for the effective delivery of DTX for breast cancer treatment.
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