Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro
A Galli, DW Crabb, E Ceni, R Salzano, T Mello… - Gastroenterology, 2002 - Elsevier
Background & Aims: The ligand-dependent transcription factor peroxisome proliferator-
activated receptor γ (PPARγ) is expressed in hepatic stellate cells (HSC), and its
transcriptional activity is reduced during cell transdifferentiation in culture. PPARγ
transcriptional activation decreases platelet-derived growth factor–induced proliferation and
inhibits α-smooth muscle actin expression in cultured HSC. The aim of our study was to
evaluate whether oral administration of synthetic PPARγ ligands, thiazolidinediones (TZD) …
activated receptor γ (PPARγ) is expressed in hepatic stellate cells (HSC), and its
transcriptional activity is reduced during cell transdifferentiation in culture. PPARγ
transcriptional activation decreases platelet-derived growth factor–induced proliferation and
inhibits α-smooth muscle actin expression in cultured HSC. The aim of our study was to
evaluate whether oral administration of synthetic PPARγ ligands, thiazolidinediones (TZD) …
[引用][C] Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cells activation in models of liver fibrosis
A Galli, E Ceni, R Salzano, T Mello, DW Crabb… - Digestive and Liver …, 2001 - infona.pl
Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cells
activation in models of liver fibrosis … Antidiabetic thiazolidinediones inhibit collagen
synthesis and hepatic stellate cells activation in models of liver fibrosis … Digestive and
Liver Disease > 2001 > 33 > Supplement 1 > A16 …
activation in models of liver fibrosis … Antidiabetic thiazolidinediones inhibit collagen
synthesis and hepatic stellate cells activation in models of liver fibrosis … Digestive and
Liver Disease > 2001 > 33 > Supplement 1 > A16 …
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