Antigen Geometry Tunes Mast Cell Signaling Through Distinct FcϵRI Aggregation and Structural Changes
DA Rinaldi, WK Kanagy, HC Kaye, RM Grattan… - bioRxiv, 2023 - biorxiv.org
Immunoreceptor tyrosine-based activation motif (ITAM)-containing Fc receptors are critical
components of the innate and adaptive immune systems. FcϵRI mediates the allergic
response via crosslinking of IgE-bound receptors by multivalent antigens. Yet, the
underlying molecular mechanisms that govern the response of FcϵRI to specific antigens
remain poorly understood. We compared responses induced by two antigens with distinct
geometries, high valency DNP-BSA and trivalent DF3, and found unique secretion and …
components of the innate and adaptive immune systems. FcϵRI mediates the allergic
response via crosslinking of IgE-bound receptors by multivalent antigens. Yet, the
underlying molecular mechanisms that govern the response of FcϵRI to specific antigens
remain poorly understood. We compared responses induced by two antigens with distinct
geometries, high valency DNP-BSA and trivalent DF3, and found unique secretion and …
[HTML][HTML] Antigen Geometry Tunes Mast Cell Signaling Through Distinct FcεRI Aggregation and Structural Changes
DA Rinaldi, WK Kanagy, HC Kaye, RM Grattan… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Immunoreceptor tyrosine-based activation motif (ITAM)-containing Fc receptors are critical
components of the innate and adaptive immune systems. FcεRI mediates the allergic
response via crosslinking of IgE-bound receptors by multivalent antigens. Yet, the
underlying molecular mechanisms that govern the response of FcεRI to specific antigens
remain poorly understood. We compared responses induced by two antigens with distinct
geometries, high valency DNP-BSA and trivalent DF3, and found unique secretion and …
components of the innate and adaptive immune systems. FcεRI mediates the allergic
response via crosslinking of IgE-bound receptors by multivalent antigens. Yet, the
underlying molecular mechanisms that govern the response of FcεRI to specific antigens
remain poorly understood. We compared responses induced by two antigens with distinct
geometries, high valency DNP-BSA and trivalent DF3, and found unique secretion and …
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