Aspirin use as a risk factor for marginal ulceration in Roux-en-Y gastric bypass patients: a meta-analysis of 24,770 patients
RC Portela, I Sharma, A Vahibe… - The American …, 2023 - journals.sagepub.com
The American Surgeon™, 2023•journals.sagepub.com
Background Roux-en-Y gastric bypass (RYGB) is a recognized, safe bariatric procedure with
minimal complications. Marginal ulceration, however, remains a challenging problem with
an incidence of 8-12%. While chronic NSAID use is an established risk factor for ulcer
formation, aspirin use itself as a cause for marginal ulceration is still unclear. We aim to
compare the rates of marginal ulceration in RYGB with and without aspirin use. Methods
PubMed, ScienceDirect, Cochrane, Web of Science, and Google Scholar were searched for …
minimal complications. Marginal ulceration, however, remains a challenging problem with
an incidence of 8-12%. While chronic NSAID use is an established risk factor for ulcer
formation, aspirin use itself as a cause for marginal ulceration is still unclear. We aim to
compare the rates of marginal ulceration in RYGB with and without aspirin use. Methods
PubMed, ScienceDirect, Cochrane, Web of Science, and Google Scholar were searched for …
Background
Roux-en-Y gastric bypass (RYGB) is a recognized, safe bariatric procedure with minimal complications. Marginal ulceration, however, remains a challenging problem with an incidence of 8-12%. While chronic NSAID use is an established risk factor for ulcer formation, aspirin use itself as a cause for marginal ulceration is still unclear. We aim to compare the rates of marginal ulceration in RYGB with and without aspirin use.
Methods
PubMed, ScienceDirect, Cochrane, Web of Science, and Google Scholar were searched for articles between 2008 and 2021 by two independent reviewers using the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA). The risk of bias was assessed using Newcastle-Ottawa Scale. Meta-analysis was conducted using a fixed-effect model.
Results
From 5324 studies screened, we included 3 studies. Two studies had a low risk of bias, and the other one presented a high risk of bias on the Newcastle-Ottawa Scale. We included 24,770 patients, 1911 with aspirin use and 22,859 without aspirin use. After the meta-analysis, patients who used aspirin had a significantly higher marginal ulceration rate than those who did not (OR = 1.33 [95% CI 1.08 to 1.63], P < .002; I2 = 39%).
Conclusions
Aspirin use is associated with increased rates of marginal ulceration after RYGB.
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