Assembly of microarrays for genome-wide measurement of DNA copy number
AM Snijders, N Nowak, R Segraves, S Blackwood… - Nature …, 2001 - nature.com
Nature genetics, 2001•nature.com
We have assembled arrays of approximately 2,400 BAC clones for measurement of DNA
copy number across the human genome. The arrays provide precise measurement (sd of
log 2 ratios= 0.05–0.10) in cell lines and clinical material, so that we can reliably detect and
quantify high-level amplifications and single-copy alterations in diploid, polyploid and
heterogeneous backgrounds.
copy number across the human genome. The arrays provide precise measurement (sd of
log 2 ratios= 0.05–0.10) in cell lines and clinical material, so that we can reliably detect and
quantify high-level amplifications and single-copy alterations in diploid, polyploid and
heterogeneous backgrounds.
Abstract
We have assembled arrays of approximately 2,400 BAC clones for measurement of DNA copy number across the human genome. The arrays provide precise measurement (sd of log 2 ratios= 0.05–0.10) in cell lines and clinical material, so that we can reliably detect and quantify high-level amplifications and single-copy alterations in diploid, polyploid and heterogeneous backgrounds.
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