Importance Before using brain volume loss (BVL) as a marker of therapeutic response in
multiple sclerosis (MS), certain biological and methodological issues must be clarified.
Objectives To assess the dynamics of BVL as MS progresses and to evaluate the
repeatability and exchangeability of BVL estimates with Jacobian Integration (JI) and
Functional Magnetic Resonance Imaging of the Brain (FMRIB) Software Library
(FSL)(specifically, the Structural Image Evaluation, Using Normalisation, of Atrophy–Cross …