Homing based gene drives (HGD) possess the potential to spread linked cargo genes into
natural populations and are poised to revolutionize population control of animals. Given that
host encoded genes have been identified that are important for pathogen transmission,
targeting these genes using guide RNAs as cargo genes linked to drives may provide a
robust method to prevent disease transmission. However, effectiveness of the inclusion of
additional guide RNAs that target separate genes has not been thoroughly explored. To test …