Association between CSF biomarkers of Alzheimer's disease and neuropsychiatric symptoms: Mayo Clinic Study of Aging
J Krell‐Roesch, M Rakusa, JA Syrjanen… - Alzheimer's & …, 2023 - Wiley Online Library
J Krell‐Roesch, M Rakusa, JA Syrjanen, AC van Harten, VJ Lowe, CR Jack Jr, WK Kremers…
Alzheimer's & Dementia, 2023•Wiley Online LibraryIntroduction We examined the association between cerebrospinal fluid (CSF)‐derived
biomarkers of Alzheimer's disease and neuropsychiatric symptoms (NPS) in older non‐
demented adults. Methods We included 784 persons (699 cognitively unimpaired, 85 with
mild cognitive impairment) aged≥ 50 years who underwent CSF amyloid beta (Aβ42),
hyperphosphorylated tau 181 (p‐tau), and total tau (t‐tau) as well as NPS assessment using
Beck Depression and Anxiety Inventories (BDI‐II, BAI), and Neuropsychiatric Inventory …
biomarkers of Alzheimer's disease and neuropsychiatric symptoms (NPS) in older non‐
demented adults. Methods We included 784 persons (699 cognitively unimpaired, 85 with
mild cognitive impairment) aged≥ 50 years who underwent CSF amyloid beta (Aβ42),
hyperphosphorylated tau 181 (p‐tau), and total tau (t‐tau) as well as NPS assessment using
Beck Depression and Anxiety Inventories (BDI‐II, BAI), and Neuropsychiatric Inventory …
Introduction
We examined the association between cerebrospinal fluid (CSF)‐derived biomarkers of Alzheimer's disease and neuropsychiatric symptoms (NPS) in older non‐demented adults.
Methods
We included 784 persons (699 cognitively unimpaired, 85 with mild cognitive impairment) aged ≥ 50 years who underwent CSF amyloid beta (Aβ42), hyperphosphorylated tau 181 (p‐tau), and total tau (t‐tau) as well as NPS assessment using Beck Depression and Anxiety Inventories (BDI‐II, BAI), and Neuropsychiatric Inventory Questionnaire (NPI‐Q).
Results
Lower CSF Aβ42, and higher t‐tau/Aβ42 and p‐tau/Aβ42 ratios were associated with BDI‐II and BAI total scores, clinical depression (BDI‐II ≥ 13), and clinical anxiety (BAI ≥ 10), as well as NPI‐Q–assessed anxiety, apathy, and nighttime behavior.
Discussion
CSF Aβ42, t‐tau/Aβ42, and p‐tau/Aβ42 ratios were associated with NPS in community‐dwelling individuals free of dementia. If confirmed by a longitudinal cohort study, the findings have clinical relevance of taking into account the NPS status of individuals with abnormal CSF biomarkers.
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