[HTML][HTML] Association between HIV and prevalent hypertension and diabetes mellitus in South Africa: analysis of a nationally representative cross-sectional survey
International Journal of Infectious Diseases, 2022•Elsevier
Objectives Cardiovascular disease (CVD) burden is increasing among persons living with
HIV (PLWH) in sub-Saharan Africa. It is unclear whether this reflects absolute increase in
HIV-related CVD risk or unmasking by improved survival. Therefore, we examined whether
HIV is associated with adverse cardiometabolic profiles among South African adults.
Methods We analyzed a nationally representative dataset (n= 6420), estimating the
weighted prevalence of hypertension, diabetes, and 10-year predicted risk of incident …
HIV (PLWH) in sub-Saharan Africa. It is unclear whether this reflects absolute increase in
HIV-related CVD risk or unmasking by improved survival. Therefore, we examined whether
HIV is associated with adverse cardiometabolic profiles among South African adults.
Methods We analyzed a nationally representative dataset (n= 6420), estimating the
weighted prevalence of hypertension, diabetes, and 10-year predicted risk of incident …
Objectives
Cardiovascular disease (CVD) burden is increasing among persons living with HIV (PLWH) in sub-Saharan Africa. It is unclear whether this reflects absolute increase in HIV-related CVD risk or unmasking by improved survival. Therefore, we examined whether HIV is associated with adverse cardiometabolic profiles among South African adults.
Methods
We analyzed a nationally representative dataset (n=6420), estimating the weighted prevalence of hypertension, diabetes, and 10-year predicted risk of incident fatal/nonfatal CVD (if aged ≥40 years). Associations between HIV and cardiometabolic indices were assessed using log-binomial regression models adjusted for sociodemographic factors.
Results
HIV population prevalence was 18.9%, with a median age of 36 years. Hypertension (44.2% vs 45.4%), diabetes (18.6% vs 20.4%), and overweight/obesity (body mass index ≥25 kg/m2: 54.9% vs 52.0%) prevalence did not substantially differ by HIV status, although PLWH had a lower 10-year predicted CVD risk (median: 5.1% vs 13.5%). In adjusted models, females who are HIV-negative had a 5 mm Hg higher median systolic blood pressure (128 vs 123 mmHg) than female PLWH.
Conclusions
PLWH in South Africa have better cardiometabolic disease profiles than the general population, and social determinants, rather than HIV, may have a greater influence on cardiometabolic risk. Designating PLWH a CVD high-risk group in South Africa is likely unwarranted.
Elsevier
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